Invention Grant
US08476484B2 Transgenic clawed frog embryos and use thereof as detectors of endocrine disrupters in the environment
有权
转基因抓青蛙胚胎及其在环境中用作内分泌干扰物的检测器
- Patent Title: Transgenic clawed frog embryos and use thereof as detectors of endocrine disrupters in the environment
- Patent Title (中): 转基因抓青蛙胚胎及其在环境中用作内分泌干扰物的检测器
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Application No.: US10516134Application Date: 2003-05-27
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Publication No.: US08476484B2Publication Date: 2013-07-02
- Inventor: Barbara Demeneix , Nathalie Turque
- Applicant: Barbara Demeneix , Nathalie Turque
- Applicant Address: FR Paris FR Paris
- Assignee: Centre National de la Recherche Scientifique (CNRS),The Museum National d'Histoire Naturelle
- Current Assignee: Centre National de la Recherche Scientifique (CNRS),The Museum National d'Histoire Naturelle
- Current Assignee Address: FR Paris FR Paris
- Agency: Foley & Lardner LLP
- Priority: FR0206669 20020530
- International Application: PCT/FR03/01598 WO 20030527
- International Announcement: WO03/102176 WO 20031211
- Main IPC: G01N33/00
- IPC: G01N33/00 ; A01K67/00 ; C12Q1/00
Abstract:
The invention relates to transgenic aquatic animals, particularly the clawed frog and the zebra fish and cells derived therefrom, characterized in comprising at least one expression cassette with a regulatory DNA sequence selected from the response elements to nuclear hormone receptors, particularly TRE, connected in a functional manner downstream of a DNA segment coding for a marker protein such as luciferase or GFP. The invention further relates to methods using the transgenic cells and animals according to the invention for the identification of endocrine disrupters in the environment.
Public/Granted literature
- US20060101528A1 Transgenic clawed frog embryos and use thereof as detectors of endocrine disrupters in the environment Public/Granted day:2006-05-11
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