A method and system suitable facilitating the connection and disconnection of a thrust reverser assembly to a fan case of a nacelle of a gas turbine engine. The method and system entail operating a clamping system to simultaneously engage and disengage flanges associated with the fan case and flanges associated with the fixed structure of the thrust reverser assembly. The clamping system includes a plurality of over-center clamping mechanisms, each of which is movable to simultaneously clamp together complementary flanges of the thrust reverser assembly and the fan case.