Flexible reinforced rubber hose adapted for conveying fluids under low temperatures and high pressures. The hose includes a inner tube formed of an acrylonitrile butadiene rubber (NBR) or other low temperature rubber compound having an elastic modulus of not greater than about 8.4 MPa (1200 psi), and an outer jacket formed of a chloroprene rubber (CR) or other low temperature rubber compound having a durometer of not greater than about 75 Shore A.