The expandable chamber acoustic silencer may be installed at the inlet or outlet of virtually any mechanism that processes air or other gas flow therethrough, to reduce the audible output of the gas flow. The silencer may be used to reduce the noise produced in an air conditioning system, in the inlet or outlet side of an air compressor, or as a muffler for an internal combustion engine, among other applications. The device includes an expansion chamber having adjustable walls driven by actuators installed within the walls to adjust the cross-sectional area of the chamber, with a portion of the walls being formed of a flexible or resilient material to enable such expansion and retraction. One or more microphones are installed at the outlet and/or inlet ends of the silencer and communicate with a controller that operates the actuators in accordance with a predetermined algorithm.