The seamless edge-sealing method of fluorine resin coating comprises following steps: (I) Putting the raw material of fluorine resin into a mold to obtain a cylinder (1) through one of the below ways: First, pressure maintaining and demolding, finally sintering the mold formed casting; Second, mechanical injecting; Third, mechanical vulcanizing; (II) Cutting the cylinder (1) into rings (3) and cutting each ring (3) to form an annular slot (31) on the inner wall of each ring; (III) Cutting a piece of base fabric of fluorine resin coating (2) into the shape adapted for the ring (3), and then stuffing the edge of the cut fabric of fluorine resin coating into the slot (31) of the ring; (IV) After hot-pressing, obtaining a piece of fabric of fluorine resin coating (4).