Invention Grant
- Patent Title: Neprilysin inhibitors
- Patent Title (中): Neprilysin抑制剂
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Application No.: US13398015Application Date: 2012-02-16
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Publication No.: US08481044B2Publication Date: 2013-07-09
- Inventor: Melissa Fleury , Roland Gendron , Adam D. Hughes
- Applicant: Melissa Fleury , Roland Gendron , Adam D. Hughes
- Applicant Address: US CA South San Francisco
- Assignee: Theravance, Inc.
- Current Assignee: Theravance, Inc.
- Current Assignee Address: US CA South San Francisco
- Agent Jeffrey A. Hagenah; Shelley Eberle
- Main IPC: A61K9/00
- IPC: A61K9/00 ; A61K31/33 ; A61K33/36 ; A61P35/00 ; C07C229/02 ; C07C271/10
Abstract:
In one aspect, the invention relates to compounds having the formula: where R1-R6, a, b, Z, and X are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and processes and intermediates for preparing such compounds.
Public/Granted literature
- US20120213806A1 NEPRILYSIN INHIBITORS Public/Granted day:2012-08-23
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