Invention Grant
US08481051B2 Cytotoxic T-cell epitope peptides that specifically attack epstein-barr virus-infected cells and uses thereof
有权
细胞毒性T细胞表位肽，特异性攻击感染细胞的病毒感染细胞及其用途
- Patent Title: Cytotoxic T-cell epitope peptides that specifically attack epstein-barr virus-infected cells and uses thereof
- Patent Title (中): 细胞毒性T细胞表位肽，特异性攻击感染细胞的病毒感染细胞及其用途
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Application No.: US12091705Application Date: 2006-10-27
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Publication No.: US08481051B2Publication Date: 2013-07-09
- Inventor: Kiyotaka Kuzushima , Yoshinori Ito , Ayako Okamura , Yoshiki Akatsuka , Yasuo Morishima
- Applicant: Kiyotaka Kuzushima , Yoshinori Ito , Ayako Okamura , Yoshiki Akatsuka , Yasuo Morishima
- Applicant Address: JP Nagoya-shi, Aichi
- Assignee: Medical and Biological Laboratories Co., Ltd.
- Current Assignee: Medical and Biological Laboratories Co., Ltd.
- Current Assignee Address: JP Nagoya-shi, Aichi
- Agency: Kilpatrick Townsend & Stockton LLP
- Priority: JP2005-315306 20051028
- International Application: PCT/JP2006/321479 WO 20061027
- International Announcement: WO2007/049737 WO 20070503
- Main IPC: A61K39/00
- IPC: A61K39/00 ; A61K38/00 ; C07K14/00
Abstract:
The present inventors introduced mRNAs for the Epstein-Barr virus proteins LMP1 and EBNA1 into antigen-presenting cells, and as a result, demonstrated that the cells induced Epstein-Barr virus-specific cytotoxic T cells. The present inventors also demonstrated that the cytotoxic T cells recognized epitope peptides presented via HLA-A*0206, HLA-Cw*0303, or HLA-Cw*0304, inhibited the outgrowth of Epstein-Barr virus-infected B cells, and lysed Epstein-Barr virus-infected NK lymphomas and NK cells.
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