Invention Grant
- Patent Title: Method of cross-linking hyaluronic acid with divinulsulfone
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Application No.: US11719790Application Date: 2005-11-24
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Publication No.: US08481080B2Publication Date: 2013-07-09
- Inventor: Fanny Longin , Khadija Schwach-Abdellaoui
- Applicant: Fanny Longin , Khadija Schwach-Abdellaoui
- Applicant Address: DK Bagsvaerd
- Assignee: Novozymes Biopolymer A/S
- Current Assignee: Novozymes Biopolymer A/S
- Current Assignee Address: DK Bagsvaerd
- Agent Jason Garbell; Eric J. Fechter
- Priority: DK200401824 20041124
- International Application: PCT/DK2005/000753 WO 20051124
- International Announcement: WO2006/056204 WO 20060601
- Main IPC: A61K9/10
- IPC: A61K9/10

Abstract:
The present invention relates to methods of producing a homogenous hydrogel comprising hyaluronic acid, or salt thereof, crosslinked with divinylsulfone (DVS), said method comprising the steps of (a) providing an alkaline solution of hyaluronic acid, or salt thereof; (b) adding DVS to the solution of step (a), whereby the hyaluronic acid, or salt thereof, is crosslinked with the DVS to form a gel; (c) treating the gel of step (b) with a buffer, wherein the gel swells and forms a hydrogel comprising hyaluronic acid, or salt thereof, crosslinked with DVS.
Public/Granted literature
- US20090155362A1 Method of cross-linking hyaluronic acid with divinulsulfone Public/Granted day:2009-06-18
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