Formulations having anti-adherent properties are disclosed herein. The anti-adherent formulation described herein acts to prevent the adherence of menses and/or fecal material to the skin in the labial and perianal regions during and after menstruation or defecation, respectively. The anti-adherent formulation contains a carrier, from about 0.1% by weight to about 10.0% by weight of a quaternary ammonium compound, and from about 0.5% by weight to about 10.0% by weight of a fatty alcohol. The anti-adherent formulation may be applied to the targeted surface either directly, in liquid form, such as by a spray bottle or similar packaging capable of delivering a liquid formulation in a relatively uniform amount over the full surface to be covered. Alternatively, the formulation may be applied to the targeted surface by a “wet” wipe or wiper.