Invention Grant
US08481496B2 Gold (III) complexes with oligopeptides functionalized with sulfur donors and use thereof as antitumor agents
有权
金（III）与与硫供体官能化的寡肽复合，并将其用作抗肿瘤剂
- Patent Title: Gold (III) complexes with oligopeptides functionalized with sulfur donors and use thereof as antitumor agents
- Patent Title (中): 金（III）与与硫供体官能化的寡肽复合，并将其用作抗肿瘤剂
-
Application No.: US13257684Application Date: 2009-03-20
-
Publication No.: US08481496B2Publication Date: 2013-07-09
- Inventor: Dolores Fregona , Luca Ronconi , Fernando Formaggio , Q. Ping Dou , Donatella Aldinucci
- Applicant: Dolores Fregona , Luca Ronconi , Fernando Formaggio , Q. Ping Dou , Donatella Aldinucci
- Applicant Address: IT Padua IT Aviano US MI Detroit
- Assignee: Universita' Degli Studi di Padova,Centro di Riferimento Oncologico,Wayne State University Board of Govenors
- Current Assignee: Universita' Degli Studi di Padova,Centro di Riferimento Oncologico,Wayne State University Board of Govenors
- Current Assignee Address: IT Padua IT Aviano US MI Detroit
- Agency: Gifford, Krass, Sprinkle, Anderson & Citkowski, P.C.
- International Application: PCT/EP2009/053296 WO 20090320
- International Announcement: WO2010/105691 WO 20100923
- Main IPC: A61K38/04
- IPC: A61K38/04
Abstract:
The invention concerns Au(III) complexes of the type [AuIIIX2(Pdtc)] (X=halogen, pseudo-halogen; pdtc=peptide-/esterified peptidedithiocarbamato) which are able to both maintain the antitumor properties and the lack of nephrotoxic side-effects of the previously reported Au(III)-dithiocarbamato complexes, together with an improved bioavailability through the peptide-mediated cellular internalization. The Au(III) complexes described have shown a significant biological activity on human tumor cell lines and, thus, they can be advantageously used as antineoplastic agents. The preparation method and use for the treatment of tumor pathologies of the Au(III) complexes of the invention are further described.
Public/Granted literature
Information query
IPC分类:
