Invention Grant
- Patent Title: Micro-RNAs that control myosin expression and myofiber identity
- Patent Title (中): 控制肌球蛋白表达和肌纤维识别的微RNA
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Application No.: US12671436Application Date: 2008-07-31
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Publication No.: US08481507B2Publication Date: 2013-07-09
- Inventor: Eric Olson , Eva van Rooij
- Applicant: Eric Olson , Eva van Rooij
- Applicant Address: US TX Austin
- Assignee: The Board of Regents, The University of Texas System
- Current Assignee: The Board of Regents, The University of Texas System
- Current Assignee Address: US TX Austin
- Agency: Cooley LLP
- International Application: PCT/US2008/071837 WO 20080731
- International Announcement: WO2009/018492 WO 20090205
- Main IPC: C12N15/11
- IPC: C12N15/11 ; C07H21/04

Abstract:
The present invention relates to the identification of two microRNAs, miR-499 and miR-208b, that repress fast skeletal muscle contractile protein genes. Expression of miR-499 and/or miR-208b can be used to repress fast fiber genes and activate slow fiber genes in the treatment of musculoskeletal disorders. Inhibition of miR-499 and/or miR-208b is proposed as a treatment for cardiac hypertrophy, myocardial infarction, and/or heart failure. Pharmaceutical compositions comprising antagonists and agonists of miR-499 and miR-208b function are also disclosed.
Public/Granted literature
- US20100269183A1 MICRO-RNAS THAT CONTROL MYOSIN EXPRESSION AND MYOFIBER IDENTITY Public/Granted day:2010-10-21
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