Invention Grant
- Patent Title: Uracyl spirooxetane nucleosides
- Patent Title (中): 尿嘧啶螺吡啶核苷
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Application No.: US13319735Application Date: 2010-05-11
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Publication No.: US08481510B2Publication Date: 2013-07-09
- Inventor: Tim Hugo Maria Jonckers , Pierre Jean-Marie Raboisson , Koen Vandyck , Steven Maurice Van Hoof , Lili Hu , Abdellah Tahri
- Applicant: Tim Hugo Maria Jonckers , Pierre Jean-Marie Raboisson , Koen Vandyck , Steven Maurice Van Hoof , Lili Hu , Abdellah Tahri
- Applicant Address: US PA Horsham SE Huddinge
- Assignee: Janssen Products, LP,Medivir AB
- Current Assignee: Janssen Products, LP,Medivir AB
- Current Assignee Address: US PA Horsham SE Huddinge
- Agent Andrea Jo Kamage
- Priority: EP09160215 20090514
- International Application: PCT/EP2010/056438 WO 20100511
- International Announcement: WO2010/130726 WO 20101118
- Main IPC: A01N43/04
- IPC: A01N43/04 ; A61K31/70 ; C07H1/00

Abstract:
Compounds of the formula I: including any possible stereoisomers thereof, wherein: R4 is a monophosphate, diphosphate or triphosphate ester; or R4 is R7 is optionally substituted phenyl, optionally substituted naphthyl, or optionally substituted indolyl; R8 and R8′ are hydrogen, C1-C6alkyl, benzyl, or phenyl; or R8 and R8′ form C3-C7cycloalkyl; R9 is C1-C10alkyl, C3-C7cycloalkyl, phenyl or phenyl-C1-C6alkyl, wherein the phenyl moiety in phenyl or phenyl-C1-C6alkyl is optionally substituted; or a pharmaceutically acceptable salt or solvate thereof; pharmaceutical formulations and the use of compounds I as HCV inhibitors.
Public/Granted literature
- US20120065156A1 Uracyl Spirooxetane Nucleosides Public/Granted day:2012-03-15
Information query
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