Invention Grant
- Patent Title: Benzamide derivatives as bradykinin antagonists
- Patent Title (中): 苯甲酰胺衍生物作为缓激肽拮抗剂
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Application No.: US12447157Application Date: 2007-10-27
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Publication No.: US08481527B2Publication Date: 2013-07-09
- Inventor: Istvan Vago , Gyula Beke , Eva Bozo , Sandor Farkas , Katalin Hornok , Gyorgy Keseru , Eva Schmidt , Eva Szentirmay , Monika Vastag
- Applicant: Istvan Vago , Gyula Beke , Eva Bozo , Sandor Farkas , Katalin Hornok , Gyorgy Keseru , Eva Schmidt , Eva Szentirmay , Monika Vastag
- Applicant Address: HU Budapest
- Assignee: Richter Gedeon Nyrt.
- Current Assignee: Richter Gedeon Nyrt.
- Current Assignee Address: HU Budapest
- Agency: Fish & Richardson P.C.
- Priority: HU0600808 20061027
- International Application: PCT/HU2007/000102 WO 20071027
- International Announcement: WO2008/068540 WO 20080612
- Main IPC: C07D207/08
- IPC: C07D207/08 ; C07D211/18 ; C07D211/44 ; C07D211/22 ; C07D211/58 ; C07D211/26 ; C07D211/62 ; C07D207/26 ; C07D211/34 ; C07D211/68 ; A61K31/18 ; A61P29/00
Abstract:
The present invention relates to new phenylsulfamoyl benzamide derivatives of formula (I) wherein R1-R5 and Z are as defined in the claims, and optical antipodes or racemates and/or salts and/or hydrates and/or solvates thereof, which are selective antagonists of bradykinin B1, to processes for producing these compounds, to pharmacological compositions containing them and to their use in therapy or prevention of painful and inflammatory conditions.
Public/Granted literature
- US20100087423A1 NEW BENZAMIDE DERIVATIVES AS BRADYKININ ANTAGONISTS Public/Granted day:2010-04-08
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