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Invention Grant
US08481539B2 Alkynylaryl compounds and salts thereof, pharmaceutical compositions comprising same, methods of preparing same and uses of same 有权
炔基芳基化合物及其盐，包含其的药物组合物，其制备方法及其用途

Alkynylaryl compounds and salts thereof, pharmaceutical compositions comprising same, methods of preparing same and uses of same
Abstract:
The invention relates to alkynylaryl compounds according to the general formula (I) in which A, B, D, E, Ra, R1, R3, R4, R5 and q are as defined in the claims, and salts, N-oxides, solvates and prodrugs thereof, to pharmaceutical compositions comprising said alkynylaryl compounds, to methods of preparing said alkynylaryl compounds, to intermediate compounds useful in said methods, to uses of said intermediate compounds in the preparation of said alkynylaryl compounds, as well as to uses of said alkynylaryl compounds for manufacturing a pharmaceutical composition for the treatment of diseases of dysregulated vascular growth or of diseases which are accompanied with dysregulated vascular growth.
Abstract(Chinese):

本发明涉及根据通式（I）的炔基芳基化合物，其中A，B，D，E，Ra，R 1，R 3，R 4，R 5和q如权利要求中所定义，和盐，N-氧化物， 包括所述炔基芳基化合物的药物组合物，制备所述炔基芳基化合物的方法，可用于所述方法的中间体化合物，所述中间体化合物在制备所述炔基芳基化合物中的用途，以及所述炔基芳基 用于制备用于治疗失调的血管生长疾病或伴随血管生长失调的疾病的药物组合物的化合物。

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