Invention Grant
- Patent Title: CGRP receptor antagonist
- Patent Title (中): CGRP受体拮抗剂
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Application No.: US13038550Application Date: 2011-03-02
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Publication No.: US08481546B2Publication Date: 2013-07-09
- Inventor: Prasad V. Chaturvedula , Gene M. Dubowchik , John E. Macor
- Applicant: Prasad V. Chaturvedula , Gene M. Dubowchik , John E. Macor
- Applicant Address: US NJ Princeton
- Assignee: Bristol-Myers Squibb Company
- Current Assignee: Bristol-Myers Squibb Company
- Current Assignee Address: US NJ Princeton
- Agent James Epperson
- Main IPC: C07D401/14
- IPC: C07D401/14 ; A61K31/496

Abstract:
The disclosure generally relates to the compound of formula I, (R)—N-(3-(7-methyl-1H-indazol-5-yl)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)-1-oxopropan-2-yl)-4-(2-oxo-1,2-dihydroquinolin-3-yl)piperidine-1-carboxamide, including pharmaceutically acceptable salts, which is a CGRP-receptor antagonist. The disclosure also relates to pharmaceutical compositions and methods for using the compound in the treatment of CGRP related disorders including migraine headaches, neurogenic vasodilation, neurogenic inflammation, thermal injury, circulatory shock, flushing associated with menopause, airway inflammatory diseases such as asthma, chronic obstructive pulmonary disease (COPD), and cancer.
Public/Granted literature
- US20120059017A1 CGRP Receptor Antagonist Public/Granted day:2012-03-08
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