Invention Grant
- Patent Title: Dual-acting thiophene, pyrrole, thiazole and furan antihypertensive agents
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Application No.: US13008262Application Date: 2011-01-18
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Publication No.: US08481549B2Publication Date: 2013-07-09
- Inventor: Paul R. Fatheree , Robert Murray McKinnell
- Applicant: Paul R. Fatheree , Robert Murray McKinnell
- Applicant Address: US CA South San Francisco
- Assignee: Theravance, Inc.
- Current Assignee: Theravance, Inc.
- Current Assignee Address: US CA South San Francisco
- Agent Jeffrey A. Hagenah; Shelley Eberle
- Main IPC: A61K31/497
- IPC: A61K31/497 ; A61K31/4436

Abstract:
In one aspect, the invention relates to compounds having the formula: wherein: Ar, Z, R3, R4 and R5 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have AT1 receptor antagonist activity and neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.
Public/Granted literature
- US20110178101A1 DUAL-ACTING THIOPHENE, PYRROLE, THIAZOLE AND FURAN ANTIHYPERTENSIVE AGENTS Public/Granted day:2011-07-21
Information query
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