Invention Grant
US08481555B2 Aza-bicyclic amine N-oxide compounds as alpha-7 nicotinic acetylcholine receptor ligand pro-drugs
有权
氮杂双环胺N-氧化物作为α-7烟碱乙酰胆碱受体配体原药
- Patent Title: Aza-bicyclic amine N-oxide compounds as alpha-7 nicotinic acetylcholine receptor ligand pro-drugs
- Patent Title (中): 氮杂双环胺N-氧化物作为α-7烟碱乙酰胆碱受体配体原药
-
Application No.: US13097153Application Date: 2011-04-29
-
Publication No.: US08481555B2Publication Date: 2013-07-09
- Inventor: Kimberley A. Lentz , Rex Denton , James H. Cook, II , Ivar M. McDonald , Dalton King , Richard E. Olson , Nenghui Wang , Robert A. Mate , Christiana I. Iwuagwu , F. Christopher Zusi , John E. Macor , Matthew D. Hill , Haiquan Fang
- Applicant: Kimberley A. Lentz , Rex Denton , James H. Cook, II , Ivar M. McDonald , Dalton King , Richard E. Olson , Nenghui Wang , Robert A. Mate , Christiana I. Iwuagwu , F. Christopher Zusi , John E. Macor , Matthew D. Hill , Haiquan Fang
- Applicant Address: US NJ Princeton
- Assignee: Bristol-Myers Squibb Company
- Current Assignee: Bristol-Myers Squibb Company
- Current Assignee Address: US NJ Princeton
- Agent James Epperson
- Main IPC: A01N43/42
- IPC: A01N43/42 ; A61K31/44 ; C07D491/10 ; C07D491/20
Abstract:
The disclosure generally relates to compounds of the following formula, including their salts, as well as compositions and methods of using the compounds. The compounds are prodrugs for ligands, agonists, and partial agonists for the nicotinic α7 receptor and may be useful for the treatment of various disorders of the central nervous system, especially affective and neurodegenerative disorders.
Public/Granted literature
- US20120108596A1 Aza-Bicyclic Amine N-Oxide Compounds as Alpha-7 Nicotinic Acetylcholine Receptor Ligand Pro-Drugs Public/Granted day:2012-05-03
Information query
IPC分类:
