Invention Grant
- Patent Title: 8-azabicyclo[3.2.1]octyl-2-hydroxybenzamide compounds as mu opioid receptor antagonists
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Application No.: US13014012Application Date: 2011-01-26
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Publication No.: US08481563B2Publication Date: 2013-07-09
- Inventor: Daisuke Roland Saito , Daniel D. Long , Priscilla Van Dyke , Timothy J. Church , Lan Jiang , Bryan Frieman
- Applicant: Daisuke Roland Saito , Daniel D. Long , Priscilla Van Dyke , Timothy J. Church , Lan Jiang , Bryan Frieman
- Applicant Address: US CA South San Francisco
- Assignee: Theravance, Inc.
- Current Assignee: Theravance, Inc.
- Current Assignee Address: US CA South San Francisco
- Agent Jeffrey A. Hagenah; Roberta P. Saxon
- Main IPC: A61K31/46
- IPC: A61K31/46 ; A61P1/00
![8-azabicyclo[3.2.1]octyl-2-hydroxybenzamide compounds as mu opioid receptor antagonists](/abs-image/US/2013/07/09/US08481563B2/abs.jpg.150x150.jpg)
Abstract:
The invention provides 8-azabicyclo[3.2.1]octyl-2-hydroxybenzamide compounds of formula (I): wherein R2, R7, and m are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are antagonists at the mu opioid receptor. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat conditions associated with mu opioid receptor activity, and processes and intermediates useful for preparing such compounds.
Public/Granted literature
- US20110118306A1 8-AZABICYCLO[3.2.1]OCTYL-2-HYDROXYBENZAMIDE COMPOUNDS AS MU OPIOID RECEPTOR ANTAGONISTS Public/Granted day:2011-05-19
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