Invention Grant
US08481566B2 Compounds which have activity at M1 receptor and their uses in medicine
失效
具有M1受体活性的化合物及其在药物中的用途
- Patent Title: Compounds which have activity at M1 receptor and their uses in medicine
- Patent Title (中): 具有M1受体活性的化合物及其在药物中的用途
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Application No.: US11852455Application Date: 2007-09-10
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Publication No.: US08481566B2Publication Date: 2013-07-09
- Inventor: Brian Budzik , David Gwyn Cooper , Ian Thomson Forbes , Vincenzo Garzya , Jian Jin , Dongchuan Shi , Graham Walker
- Applicant: Brian Budzik , David Gwyn Cooper , Ian Thomson Forbes , Vincenzo Garzya , Jian Jin , Dongchuan Shi , Graham Walker
- Applicant Address: GB Greenford, Middlesex
- Assignee: Glaxo Group Limited
- Current Assignee: Glaxo Group Limited
- Current Assignee Address: GB Greenford, Middlesex
- Agent Linda E. Hall; John L. Lemanowicz
- Priority: GB0519950.0 20050930; GB0602040.8 20060201
- Main IPC: A61K31/445
- IPC: A61K31/445 ; C07D401/04

Abstract:
Compounds of formula (I) and salts and solvates are provided: wherein R4 is fluoro, R5 is selected from hydrogen, halogen, cyano, C1-6alkyl, C1-6alkyl substituted with one or more fluorine atoms, C1-6alkoxy, and C1-6alkoxy substituted with one or more fluorine atoms; and R6 is selected from halogen, cyano, C1-6alkyl, C1-6alkyl substituted with one or more fluorine atoms, C3-6cycloalkyl, C3-6cycloalkyl substituted with one or more fluorine atoms, C1-6alkoxy and C1-6alkoxy substituted with one or more fluorine atoms, and Q is hydrogen or C1-6alkyl. The compounds are expected to be useful for therapy, for example in the treatment of psychotic disorders and cognitive impairment.
Public/Granted literature
- US20080058378A1 Compounds which have activity at M1 receptor and their uses in medicine. Public/Granted day:2008-03-06
Information query
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