Invention Grant
- Patent Title: Synthesis of epothilones, intermediates thereto, analogues and uses thereof
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Application No.: US13040211Application Date: 2011-03-03
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Publication No.: US08481575B2Publication Date: 2013-07-09
- Inventor: Samuel J. Danishefsky , Peter Bertinato , Dai-shi Su , Dongfang Meng , Ting-Chao Chou , Ted Kamenecka , Erik J. Sorensen , Aaron Balog , Kenneth A. Savin
- Applicant: Samuel J. Danishefsky , Peter Bertinato , Dai-shi Su , Dongfang Meng , Ting-Chao Chou , Ted Kamenecka , Erik J. Sorensen , Aaron Balog , Kenneth A. Savin
- Applicant Address: US NY New York
- Assignee: Sloan-Kettering Institute for Cancer Research
- Current Assignee: Sloan-Kettering Institute for Cancer Research
- Current Assignee Address: US NY New York
- Agency: Choate, Hall & Stewart LLP
- Agent Brenda Herschbach Jarrell; Kristen C. Buteau
- Main IPC: A61K31/426
- IPC: A61K31/426 ; C07D277/30
Abstract:
The present invention provides convergent processes for preparing epothilone A and B, desoxyepothilones A and B, and analogues thereof. Also provided are analogues related to epothilone A and B and intermediates useful for preparing same. The present invention further provides novel compositions based on analogues of the epothilones and methods for the treatment of cancer and cancer which has developed a multidrug-resistant phenotype.
Public/Granted literature
- US20110263663A1 SYNTHESIS OF EPOTHILONES, INTERMEDIATES THERETO, ANALOGUES AND USES THEREOF Public/Granted day:2011-10-27
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