Invention Grant
US08481582B2 1,3-dihydroimidazole-2-thione derivatives as inhibitors of dopamine-beta-hydroxylase 有权
1,3-二氢咪唑-2-硫酮衍生物作为多巴胺-β-羟化酶的抑制剂

1,3-dihydroimidazole-2-thione derivatives as inhibitors of dopamine-beta-hydroxylase
Abstract:
Compounds of formula I and a method for their preparation are described: where R1, R2 and R3 are the same or different and signify hydrogens, halogens, alkyl, nitro, amino, alkylcarbonylamino, alkylamino or dialkylamino group; R4 signifies -alkyl-aryl or -alkyl-heteroaryl; X signifies CH2, oxygen atom or sulphur atom; n is 2 or 3; including the individual (R)- and (S)-enantiomers or mixtures of enantiomers thereof; and including pharmaceutically acceptable salts and esters thereof. The compounds have potentially valuable pharmaceutical properties for the treatment of cardiovascular disorders such as hypertension and chronic heart failure.
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