Invention Grant
US08481582B2 1,3-dihydroimidazole-2-thione derivatives as inhibitors of dopamine-beta-hydroxylase
有权
1,3-二氢咪唑-2-硫酮衍生物作为多巴胺-β-羟化酶的抑制剂
- Patent Title: 1,3-dihydroimidazole-2-thione derivatives as inhibitors of dopamine-beta-hydroxylase
- Patent Title (中): 1,3-二氢咪唑-2-硫酮衍生物作为多巴胺-β-羟化酶的抑制剂
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Application No.: US12599014Application Date: 2008-05-06
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Publication No.: US08481582B2Publication Date: 2013-07-09
- Inventor: Patrício Manuel Vieira Araújo Soares Da Silva , David Alexander Learmonth , Alexander Beliaev
- Applicant: Patrício Manuel Vieira Araújo Soares Da Silva , David Alexander Learmonth , Alexander Beliaev
- Applicant Address: PT S. Mamede Do Coronado
- Assignee: Bial-Portela & CA, S.A.
- Current Assignee: Bial-Portela & CA, S.A.
- Current Assignee Address: PT S. Mamede Do Coronado
- Agency: McCarter & English, LLP
- Agent Steven G. Davis; Wei Song
- Priority: GB0708818.0 20070508
- International Application: PCT/PT2008/000019 WO 20080506
- International Announcement: WO2008/136695 WO 20081113
- Main IPC: A61K31/4178
- IPC: A61K31/4178 ; C07D207/48

Abstract:
Compounds of formula I and a method for their preparation are described: where R1, R2 and R3 are the same or different and signify hydrogens, halogens, alkyl, nitro, amino, alkylcarbonylamino, alkylamino or dialkylamino group; R4 signifies -alkyl-aryl or -alkyl-heteroaryl; X signifies CH2, oxygen atom or sulphur atom; n is 2 or 3; including the individual (R)- and (S)-enantiomers or mixtures of enantiomers thereof; and including pharmaceutically acceptable salts and esters thereof. The compounds have potentially valuable pharmaceutical properties for the treatment of cardiovascular disorders such as hypertension and chronic heart failure.
Public/Granted literature
- US20100137390A1 1,3-Dihydroimidazole-2-Thione Derivatives as Inhibitors of Dopamine-Beta-Hydroxylase Public/Granted day:2010-06-03
Information query
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