Invention Grant
- Patent Title: Compounds for the treatment of metabolic disorders
- Patent Title (中): 用于治疗代谢紊乱的化合物
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Application No.: US12812514Application Date: 2009-01-13
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Publication No.: US08481595B2Publication Date: 2013-07-09
- Inventor: Shalini Sharma , Reid W. von Borstel
- Applicant: Shalini Sharma , Reid W. von Borstel
- Applicant Address: US MD Gaithersburg
- Assignee: Wellstat Therapeutics Corporation
- Current Assignee: Wellstat Therapeutics Corporation
- Current Assignee Address: US MD Gaithersburg
- Agent Lewis J. Kreisler
- International Application: PCT/US2009/030845 WO 20090113
- International Announcement: WO2009/091732 WO 20090723
- Main IPC: A01N37/10
- IPC: A01N37/10 ; A61K31/325 ; C07C69/76

Abstract:
Agents useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, polycystic ovary syndrome, hyperlipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis are disclosed. The agent is a compound of Formula (I): wherein m is 0, 1, 2, 3, 4, 5, 6, 7 or 8; R1 is hydrogen or alkyl having from 1 to 3 carbon atoms; and R2 is hydrogen, halo, alkyl having from 1 to 3 carbon atoms, or alkoxy having from 1 to 3 carbon atoms. A is phenyl, unsubstituted or substituted by 1 or 2 groups selected from: halo, hydroxy, alkyl having 1 or 2 carbon atoms, perfluoromethyl, alkoxy having 1 or 2 carbon atoms, and perfluoromethoxy; or cycloalkyl having from 3 to 6 ring carbon atoms wherein the cycloalkyl is unsubstituted or one or two ring carbons are independently mono-substituted by methyl or ethyl; or a 5 or 6 membered heteroaromatic ring having 1 or 2 ring heteroatoms selected from N, S and O and the heteroaromatic ring is covalently bound to the remainder of the compound of formula I by a ring carbon; Alternatively, the agent can be a pharmaceutically acceptable salt of the compound of Formula (I).
Public/Granted literature
- US20100286267A1 COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS Public/Granted day:2010-11-11
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