Invention Grant
US08481673B2 Bio-degradable/absorbable polymer having reduced metal catalyst content, and process for production thereof 失效
具有降低的金属催化剂含量的生物可降解/可吸收聚合物及其生产方法

Bio-degradable/absorbable polymer having reduced metal catalyst content, and process for production thereof
Abstract:
The present invention provides a method for reducing the content of a metal catalyst in a biodegradable and absorbable polymer that can be applied on an industrial scale and a method for producing a biodegradable and bioabsorbable polymer having a metal catalyst content of less than 1 ppm in terms of a metal. The method includes the steps of (1) copolymerizing lactide and ε-caprolactone at a molar ratio ranging from 40/60 to 60/40 or 65/35 to 85/15 in the presence of the metal catalyst to produce a copolymer; and (2) washing the copolymer with a mixed solvent comprising acetic acid and isopropanol at a volume ratio ranging from 25/75 to 45/55 or 45/55 to 55/45 at less than 40° C., and drying the copolymer.
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