Invention Grant
- Patent Title: Glycosylated glycopeptide antibiotic derivatives
- Patent Title (中): 糖基化糖肽抗生素衍生物
-
Application No.: US12810507Application Date: 2008-12-25
-
Publication No.: US08481696B2Publication Date: 2013-07-09
- Inventor: Kouhei Matsui , Kazuyuki Minagawa , Osamu Yoshida , Kenji Morimoto , Yuuki Ogata
- Applicant: Kouhei Matsui , Kazuyuki Minagawa , Osamu Yoshida , Kenji Morimoto , Yuuki Ogata
- Applicant Address: JP Osaka
- Assignee: Shionogi & Co., Ltd.
- Current Assignee: Shionogi & Co., Ltd.
- Current Assignee Address: JP Osaka
- Agency: Finnegan, Henderson, Farabow, Garrett & Dunner, LLP
- Priority: JP2007-333408 20071226
- International Application: PCT/JP2008/073511 WO 20081225
- International Announcement: WO2009/081958 WO 20090702
- Main IPC: A61K31/7032
- IPC: A61K31/7032 ; A61K31/7048 ; C07H15/203 ; C07H15/24

Abstract:
The present invention provides novel glycopeptides antibiotic derivatives comprising a sugar residue (I) represented by the formula: (wherein n is an integer of 1 to 5: Sugs are each independently a monosaccharide, (Sug)n is a divalent sugar residue formed by binding of same or different 1 to 5 monosaccharides; RA1 is optionally substituted lower alkyl, optionally substituted lower alkenyl, or optionally substituted cycloalkyl; and RE is OH or NHAc (Ac is acetyl)) is bound to an aromatic ring of the fourth amino acid residue in the glycopeptide skeleton. These derivatives have antibacterial activity against vancomycin-resistant bacteria.
Public/Granted literature
- US20100286364A1 GLYCOSYLATED GLYCOPEPTIDE ANTIBIOTIC DERIVATIVES Public/Granted day:2010-11-11
Information query
IPC分类: