Invention Grant
- Patent Title: Parallel proximity ligation event analysis
- Patent Title (中): 平行邻近结扎事件分析
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Application No.: US12407547Application Date: 2009-03-19
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Publication No.: US08481698B2Publication Date: 2013-07-09
- Inventor: Erez Lieberman , Andreas Gnirke , Daniel Aird
- Applicant: Erez Lieberman , Andreas Gnirke , Daniel Aird
- Applicant Address: US MA Cambridge US MA Cambridge
- Assignee: The President and Fellows of Harvard College,Massachusetts Institute of Technology
- Current Assignee: The President and Fellows of Harvard College,Massachusetts Institute of Technology
- Current Assignee Address: US MA Cambridge US MA Cambridge
- Agency: Medlen & Carroll, LLP
- Main IPC: C12N15/11
- IPC: C12N15/11 ; C07H21/04
Abstract:
The present invention describes compositions and methods showing that the spatial proximity of intracellular components may be related to their ability to cooperate in intracellular biochemical reactions. In some embodiments, the present invention contemplates a variety of nucleic acid barcoded binding partners capable of determining the spatial proximity of intracellular components as determined by ligation of their respective nucleotide barcodes. As such, an intracellular component contact map may be constructed to fingerprint specific physiological and/or pharmacological intracellular conditions.
Public/Granted literature
- US20100240101A1 Parallel Proximity Ligation Event Analysis Public/Granted day:2010-09-23
Information query
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