Invention Grant
US08481704B2 Nucleic acid molecule encoding human GM-CSF antigen binding proteins
有权
编码人GM-CSF抗原结合蛋白的核酸分子
- Patent Title: Nucleic acid molecule encoding human GM-CSF antigen binding proteins
- Patent Title (中): 编码人GM-CSF抗原结合蛋白的核酸分子
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Application No.: US13589935Application Date: 2012-08-20
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Publication No.: US08481704B2Publication Date: 2013-07-09
- Inventor: Jacqueline A. Kirchner , Kenneth A. Brasel , Kara Olson , Jose Carlos Escobar , Dauphine Barone
- Applicant: Jacqueline A. Kirchner , Kenneth A. Brasel , Kara Olson , Jose Carlos Escobar , Dauphine Barone
- Applicant Address: US CA Thousand Oaks
- Assignee: Amgen Inc.
- Current Assignee: Amgen Inc.
- Current Assignee Address: US CA Thousand Oaks
- Agent Susan E. Lingenfelter
- Main IPC: C07H21/04
- IPC: C07H21/04 ; C12P21/08 ; C12N15/10
Abstract:
Antigen binding proteins that bind to human GM-CSF protein are provided. Nucleic acids encoding the antigen binding protein, vectors, and cells encoding the same are also provided. The antigen binding proteins can inhibit binding of GM-CSF to GM-CSFR, inhibit GM-CSF-induced proliferation and signaling of myeloid lineage cell lines and inhibit GM-CSF-induced activation of human monocytes.
Public/Granted literature
- US20130071923A1 HUMAN GM-CSF ANTIGEN BINDING PROTEINS Public/Granted day:2013-03-21
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