Invention Grant
- Patent Title: Preparation of alkyl-substituted 2-deoxy-2-fluoro-D-ribofuranosyl pyrimidines and purines and their derivatives
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Application No.: US12786459Application Date: 2010-05-25
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Publication No.: US08481713B2Publication Date: 2013-07-09
- Inventor: Peiyuan Wang , Wojciech Stec , Byoung Kwon Chun , Junxing Shi , Jinfa Du
- Applicant: Peiyuan Wang , Wojciech Stec , Byoung Kwon Chun , Junxing Shi , Jinfa Du
- Applicant Address: US CA Foster City
- Assignee: Gilead Pharmasset LLC
- Current Assignee: Gilead Pharmasset LLC
- Current Assignee Address: US CA Foster City
- Agency: Fitzpatrick, Cella, Harper & Scinto
- Main IPC: C07H19/20
- IPC: C07H19/20 ; C07H3/00
Abstract:
The present invention provides (i) a process for preparing a 2-deoxy-2-fluoro-2-methyl-D-ribonolactone derivative, (ii) conversion of the lactone to nucleosides with potent anti-HCV activity, and their analogues, and (iii) a method to prepare the anti-HCV nucleosides containing the 2-deoxy-2-fluoro-2-C-methyl-β-D-ribofuranosyl nucleosides from a preformed, preferably naturally-occurring, nucleoside.
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