Invention Grant
US08481740B2 Imidazo[1,2 a] pyridine-6-carboxamide derivatives, their use for the treatment of colon cancer and their method of manufacture
失效
咪唑并[1,2a]吡啶-6-甲酰胺衍生物，其用于治疗结肠癌及其制造方法
![Imidazo[1,2 a] pyridine-6-carboxamide derivatives, their use for the treatment of colon cancer and their method of manufacture](/docs/US/2013-07-09/US08481740B2/abs.jpg.600x600.jpg)
- Patent Title: Imidazo[1,2 a] pyridine-6-carboxamide derivatives, their use for the treatment of colon cancer and their method of manufacture
- Patent Title (中): 咪唑并[1,2a]吡啶-6-甲酰胺衍生物，其用于治疗结肠癌及其制造方法
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Application No.: US13263172Application Date: 2010-04-01
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Publication No.: US08481740B2Publication Date: 2013-07-09
- Inventor: Nurit Esperance Farkas (Nee Dahan) , Hajierah Davids , Candice Langley , Charles Bernard De Koning
- Applicant: Nurit Esperance Farkas (Nee Dahan) , Hajierah Davids , Candice Langley , Charles Bernard De Koning
- Applicant Address: ZA Johannesburg
- Assignee: University of the Witwatersrand, Johannesburg
- Current Assignee: University of the Witwatersrand, Johannesburg
- Current Assignee Address: ZA Johannesburg
- Agency: Ladas & Parry LLP
- Priority: ZA2009/00360 20090407
- International Application: PCT/IB2010/051427 WO 20100401
- International Announcement: WO2010/116302 WO 20101014
- Main IPC: C07D471/04
- IPC: C07D471/04
![Imidazo[1,2 a] pyridine-6-carboxamide derivatives, their use for the treatment of colon cancer and their method of manufacture](/abs-image/US/2013/07/09/US08481740B2/abs.jpg.150x150.jpg)
Abstract:
This invention relates to the manufacture of novel chemical compounds which have biological activity, particularly to novel chemical compounds that are cytotoxic against colon cancer cells and colon cancer cell lines. The manufacturing of said chemical compounds displaying anti-cancer properties employs the use of multi-component chemical reactions. The object of this invention is to manufacture and isolate analogues of imidazo[1,2-a]pyridine, namely compounds of Formula 1, which are cytotoxic against colon cancer cells, while concomitantly being relatively inactive against white blood cells. wherein, R is bromo, methyl, phenyl, nitro, hydrogen or an amide functional group; R1 is benzyl, 2,6-dimethylphenyl or cyclohexyl; and R2 is methoxy, benzyloxy or hydroxy.
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