Invention Grant
US08481779B2 Method for producing N-substituted-2-amino-4-(hydroxymethylphosphinyl)-2-butenoic acid 有权
N-取代-2-氨基-4-(羟甲基氧膦基)-2-丁烯酸的制备方法

Method for producing N-substituted-2-amino-4-(hydroxymethylphosphinyl)-2-butenoic acid
Abstract:
Provided is a method for producing a compound expressed by the following formula (3): [where R1 represents a hydrogen atom or C1-4 alkyl group, and R2 represents C1-4 alkyl group, C1-4 alkoxy group, aryl group, aryloxy group or benzyloxy group], the method comprising a reaction of dehydro-condensing a compound expressed by the following formula (1) and a compound expressed by the following formula (2): while being converted to a desired geometric isomer in the presence or absence of an acid catalyst, under a condition that an organic solvent to be used for the reaction is a mixed solvent of acetic acid and a solvent selected from the group consisting of toluene, xylene and chlorobenzene.
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