Invention Grant
US08481779B2 Method for producing N-substituted-2-amino-4-(hydroxymethylphosphinyl)-2-butenoic acid
有权
N-取代-2-氨基-4-(羟甲基氧膦基)-2-丁烯酸的制备方法
- Patent Title: Method for producing N-substituted-2-amino-4-(hydroxymethylphosphinyl)-2-butenoic acid
- Patent Title (中): N-取代-2-氨基-4-(羟甲基氧膦基)-2-丁烯酸的制备方法
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Application No.: US13579135Application Date: 2011-06-14
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Publication No.: US08481779B2Publication Date: 2013-07-09
- Inventor: Takashi Ando , Nobuto Minowa , Masaaki Mitomi
- Applicant: Takashi Ando , Nobuto Minowa , Masaaki Mitomi
- Applicant Address: JP Tokyo
- Assignee: Meiji Seika Pharma Co., Ltd.
- Current Assignee: Meiji Seika Pharma Co., Ltd.
- Current Assignee Address: JP Tokyo
- Agency: Greenblum & Bernstein, P.L.C.
- Priority: JP2010-136373 20100615
- International Application: PCT/JP2011/063546 WO 20110614
- International Announcement: WO2011/158813 WO 20111221
- Main IPC: C07F9/30
- IPC: C07F9/30

Abstract:
Provided is a method for producing a compound expressed by the following formula (3): [where R1 represents a hydrogen atom or C1-4 alkyl group, and R2 represents C1-4 alkyl group, C1-4 alkoxy group, aryl group, aryloxy group or benzyloxy group], the method comprising a reaction of dehydro-condensing a compound expressed by the following formula (1) and a compound expressed by the following formula (2): while being converted to a desired geometric isomer in the presence or absence of an acid catalyst, under a condition that an organic solvent to be used for the reaction is a mixed solvent of acetic acid and a solvent selected from the group consisting of toluene, xylene and chlorobenzene.
Public/Granted literature
- US20120316358A1 METHOD FOR PRODUCING N-SUBSTITUTED-2-AMINO-4-(HYDROXYMETHYLPHOSPHINYL)-2-BUTENOIC ACID Public/Granted day:2012-12-13
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