The hybrid multiple-input multiple-output antenna module includes a grounding unit, a plurality of radiating units, loop units and filter units. The radiating units and the loop units are arranged around a geometric center of the grounding unit and are alternately and symmetrically arranged on the grounding unit. The loop units are arranged along the outer peripheral side of the grounding unit. The filter units are respectively electrically connected to the loop units. The present invention not only has some advantages such as small size, low profile, good isolation, high antenna gain and good radiation properties, but also can replace the external dual-band access-point antenna of the prior art for 2.4/5 GHz operation with no need of an extra diplexer. In addition, the hybrid multiple-input multiple-output antenna module can be hidden in the wireless communication device in order to enhance the appearance of the product.