Methods and apparatus for achieving adaptive de-emphasis on a data network. In one embodiment, the network comprises a high-speed serialized bus network, and the invention is adapted to correct for inter-symbol interference (ISI) associated with data transmissions between two nodes communicating over the network. In one variant, a first device transmits a plurality of symbols to a second device. If the second device detects that these symbols have unacceptably degraded during transmission, it generates an interrupt during a designated interval that is subsequently transmitted to the first device, and used to either attenuate the signal strength associated with data transmissions to the second device, or undertake one or more remedial measures. In another embodiment, sequential calibration of nodes is achieved by executing a process adapted to identify an optimal de-emphasis level associated with data transmissions.