Invention Grant
US08483970B2 Method for identifying aQTL regions whose genotype modulates transcription factor activity
有权
鉴定基因型调节转录因子活性的QTL区域的方法
- Patent Title: Method for identifying aQTL regions whose genotype modulates transcription factor activity
- Patent Title (中): 鉴定基因型调节转录因子活性的QTL区域的方法
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Application No.: US12569794Application Date: 2009-09-29
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Publication No.: US08483970B2Publication Date: 2013-07-09
- Inventor: Harmen J. Bussemaker , Eunjee Lee
- Applicant: Harmen J. Bussemaker , Eunjee Lee
- Applicant Address: US NY New York
- Assignee: The Trustees of Columbia University in the city of New York
- Current Assignee: The Trustees of Columbia University in the city of New York
- Current Assignee Address: US NY New York
- Agency: Baker Botts, L.L.P.
- Main IPC: G06F19/00
- IPC: G06F19/00 ; C12Q1/68
Abstract:
The disclosed subject matter is directed to genetic linkage methods for identifying genetic determinants of transcription factor activity. An inferred transcription factor activity profile is generated based on a nucleotide sequence-specific mathematical model of gene expression regulation. Genetic linkage analysis is performed to identify at least one genetic determinant linked to a specific transcription factor segregant based on the inferred transcription factor profile.
Public/Granted literature
- US20100153018A1 Method for Identifying Genetic Determinants of Transcription Factor Activity Public/Granted day:2010-06-17
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