Detection and reduction of unaligned input/output (“I/O”) requests is implemented by a storage server determining an alignment value for data stored by the server within a storage system on behalf of a first client, writing the alignment value to a portion of the volume that stores the data for the first client, but not to a portion of the volume that stores data for a second client, and changing a location of data within the portion of the volume that stores the data for the first client, but not a location of data in the portion of the volume that stores data for the second client, to an alignment corresponding to the alignment value. The alignment value is applied to I/O requests directed to the portion of the volume that stores the data blocks for the first client after the location of the data blocks has been changed.