Systems and methods are disclosed to automatically generate a custom integrated circuit (IC) design by receiving a specification of the custom IC including computer readable code to be executed by the custom IC; generating an abstraction of the IC as a system, processor architecture and micro-architecture (SAMA) representation; providing the SAMA representation to a data model having at least an architecture optimization view, a physical design view, and a software tool view; optimizing the processor architecture by iteratively updating the SAMA representation and the data model to automatically generate a processor architecture uniquely customized to the computer readable code which satisfies one or more constraints; and synthesizing the generated architecture into a computer readable description of the custom integrated circuit for semiconductor fabrication. The foregoing can be done with no or minimal human involvement.