Invention Grant
- Patent Title: Itraconazole compositions with improved bioavailability
- Patent Title (中): 具有改善的生物利用度的伊曲康唑组合物
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Application No.: US11997256Application Date: 2006-08-08
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Publication No.: US08486456B2Publication Date: 2013-07-16
- Inventor: Gunther Berndl , Matthias Degenhardt , Markus Mäegerlein , Gerrit Dispersyn
- Applicant: Gunther Berndl , Matthias Degenhardt , Markus Mäegerlein , Gerrit Dispersyn
- Applicant Address: DE Wiesbaden
- Assignee: Abbott GmbH & Co., KG
- Current Assignee: Abbott GmbH & Co., KG
- Current Assignee Address: DE Wiesbaden
- Agency: Saul Ewing LLP
- Agent Paul C. Lauro, Esq.
- International Application: PCT/EP2006/007839 WO 20060808
- International Announcement: WO2007/017248 WO 20070215
- Main IPC: A61K9/14
- IPC: A61K9/14 ; A61K31/497
Abstract:
A solid dispersion product comprising itraconazole and hydroxypropyl methylcellulose, which satisfies the Formula 0.35>ΔHtr (1) (wherein ΔHtr represents the endotherm (J/g) accompanying a transition at about 240° C). The solid dispersion product shows an improved bioavailability.
Public/Granted literature
- US20090214656A1 ITRACONAZOLE COMPOSITIONS WITH IMPROVED BIOAVAILABILITY Public/Granted day:2009-08-27
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