Invention Grant
US08486642B2 Method of synthesizing 1,3-cyclohexadione derived reagents useful for detection or isolation of sulfenic acid-containing compounds
有权
合成可用于检测或分离含亚磺酸化合物的1,3-环己二酮衍生试剂的方法
- Patent Title: Method of synthesizing 1,3-cyclohexadione derived reagents useful for detection or isolation of sulfenic acid-containing compounds
- Patent Title (中): 合成可用于检测或分离含亚磺酸化合物的1,3-环己二酮衍生试剂的方法
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Application No.: US12861529Application Date: 2010-08-23
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Publication No.: US08486642B2Publication Date: 2013-07-16
- Inventor: Leslie B. Poole , S. Bruce King , Jacquelyn S. Fetrow
- Applicant: Leslie B. Poole , S. Bruce King , Jacquelyn S. Fetrow
- Applicant Address: US NC Winston-Salem
- Assignee: Wake Forest University Health Sciences
- Current Assignee: Wake Forest University Health Sciences
- Current Assignee Address: US NC Winston-Salem
- Agency: Myers Bigel Sibley & Sajovec, P.A.
- Main IPC: G01N33/53
- IPC: G01N33/53 ; C07C229/56 ; C07D311/16
Abstract:
The present invention provides a method of synthesizing compounds of Formula I: wherein: R1 is a label (e.g., a detectable groups; an anti-tumor agents); L is present or absent and when present is a linking group; and x represents an integer from 1 to 10; or a pharmaceutically acceptable salt thereof. the compounds are useful for, among other things, identifying cysteine sulfenic acids in proteins and monitoring oxidative damage in proteins and cells.
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