Invention Grant
US08487072B2 Compounds for stimulating P-glycoprotein function and uses thereof
失效
用于刺激P-糖蛋白功能的化合物及其用途
- Patent Title: Compounds for stimulating P-glycoprotein function and uses thereof
- Patent Title (中): 用于刺激P-糖蛋白功能的化合物及其用途
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Application No.: US12446434Application Date: 2007-10-19
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Publication No.: US08487072B2Publication Date: 2013-07-16
- Inventor: Richard Beliveau , Michel Demeule , Stephane Barakat , Jonathan Michaud-Levesque
- Applicant: Richard Beliveau , Michel Demeule , Stephane Barakat , Jonathan Michaud-Levesque
- Applicant Address: CA Montreal
- Assignee: Angiochem Inc.
- Current Assignee: Angiochem Inc.
- Current Assignee Address: CA Montreal
- Agency: Clark & Elbing LLP
- Agent Kristina Bieker-Brady
- International Application: PCT/CA2007/001861 WO 20071019
- International Announcement: WO2008/046228 WO 20080424
- Main IPC: A61K38/10
- IPC: A61K38/10 ; C07K7/08
Abstract:
The present invention is directed to polypeptides (e.g., fragments) derived from P-glycoprotein and caveolin-1 which are capable of inhibiting the interaction between these two proteins. Inhibition of this interaction leads to increase of efflux of compounds that are transported by P-gp. The invention further includes methods of treating patients having diseases that benefit from increased P-gp-mediated efflux. Such diseases include neoplasms such as cancer and neurological diseases such as neurodegenerative diseases.
Public/Granted literature
- US20110218152A1 COMPOUNDS FOR STIMULATING P-GLYCOPROTEIN FUNCTION AND USES THEREOF Public/Granted day:2011-09-08
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