Invention Grant
US08487082B2 Synthetic scFv analogue to the 6313/G2 (anti angiotensin II type 1 receptor) monoclonal antibody variable regions
有权
合成scFv类似于6313 / G2（抗血管紧张素II 1型受体）单克隆抗体可变区
- Patent Title: Synthetic scFv analogue to the 6313/G2 (anti angiotensin II type 1 receptor) monoclonal antibody variable regions
- Patent Title (中): 合成scFv类似于6313 / G2（抗血管紧张素II 1型受体）单克隆抗体可变区
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Application No.: US12867911Application Date: 2009-02-18
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Publication No.: US08487082B2Publication Date: 2013-07-16
- Inventor: Gavin Paul Vinson , Stewart Barker , John Richard Puddefoot
- Applicant: Gavin Paul Vinson , Stewart Barker , John Richard Puddefoot
- Applicant Address: GB London
- Assignee: Queen Mary & Westfield College
- Current Assignee: Queen Mary & Westfield College
- Current Assignee Address: GB London
- Agency: Pepper Hamilton, LLP
- Priority: GB0802931.6 20080218
- International Application: PCT/GB2009/000443 WO 20090218
- International Announcement: WO2009/103969 WO 20090827
- Main IPC: C07K16/00
- IPC: C07K16/00 ; A61K39/395
Abstract:
The present invention provides a specific binding molecule which specifically binds to a peptide having the amino acid sequence of EDGIKRIQDD and comprises a polypeptide having an immunoglobulin VL domain linked to an immunoglobulin VH domain in which the VL domain comprises Complementarity Determining Regions (CDRs) VLCDR1, VLCDR2 and VLCDR3, and in which the VH domain comprises Complementarity Determining Regions (CDRs) VHCDR1, VHCDR2, VHCDR3, each having a respective amino acid sequence as follows in which VHCDR1 is GYSFTGYNMN VHCDR2 is NIDPYYGGTTYNQKFKG VHCDR3 is EVDY VLCDR1 is RASKSVSTSTSGYSYMH VLCDR2 is LVSNLES VLCDR3 is QHIRELTRSEG or an amino acid sequence at least 70% identical thereto.
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