Invention Grant
US08487157B2 Transgenic rodents having NGF beta gene mutants and its preparation methods, the preparation methods of the corresponding mutant proteins and the resulting mutant proteins
有权
具有NGFβ基因突变体的转基因啮齿动物及其制备方法，相应的突变蛋白的制备方法和所得的突变蛋白
- Patent Title: Transgenic rodents having NGF beta gene mutants and its preparation methods, the preparation methods of the corresponding mutant proteins and the resulting mutant proteins
- Patent Title (中): 具有NGFβ基因突变体的转基因啮齿动物及其制备方法，相应的突变蛋白的制备方法和所得的突变蛋白
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Application No.: US12812731Application Date: 2008-03-07
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Publication No.: US08487157B2Publication Date: 2013-07-16
- Inventor: Zhiwen Zhou , Hongshan Zhang , Hongbo Chen
- Applicant: Zhiwen Zhou , Hongshan Zhang , Hongbo Chen
- Applicant Address: CN Beijing
- Assignee: Staidson (Beijing) Pharmaceutical Co., Ltd.
- Current Assignee: Staidson (Beijing) Pharmaceutical Co., Ltd.
- Current Assignee Address: CN Beijing
- Agency: Sughrue Mion, PLLC
- Priority: CN200710086017 20070307
- International Application: PCT/CN2008/070438 WO 20080307
- International Announcement: WO2008/106896 WO 20080912
- Main IPC: A01K67/027
- IPC: A01K67/027 ; A01K67/033
Abstract:
Transgenic rodents having NGF beta gene mutants in their genomes express NGF beta mutant proteins. The preparation methods of the transgenic rodents, the methods of utilizing the transgenic animals to prepare NGF beta mutant proteins and the resulting NGF beta mutant proteins are provided. The transgenic rodents are useful in preparing human NGF and in the study of the functions of NGF beta mutants and their receptors in the whole animal level, and also useful for screening and purifying NGF beta mutants which have high activity and high security.
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