Systems and methods for the coordination of benefits in healthcare claim transactions are provided. A healthcare claim request including information associated with a plurality of prescription claims for a single healthcare transaction may be received from a healthcare provider computer and identified as a bundled healthcare claim request. A primary claim request for the healthcare transaction may be generated and communicated to a first claims processor computer for adjudication, and a first adjudicated reply may be received from the first claims processor computer. Based at least in part on the received first adjudicated reply, a secondary claim request for the healthcare transaction may be generated and communicated to a second claims processor computer for adjudication. A second adjudicated reply may be received from the second claims processor, and information associated with the first adjudicated reply and the second adjudicated reply may be communicated to the healthcare provider computer.