A technique for incrementally unloading classes using a region-based garbage collector is described. One aspect of such a technique includes maintaining a remembered set for a class set. The remembered set indicates whether instances of the class set are contained in one or more regions in memory, and in which regions the instances are contained. Upon performing an incremental garbage collection process for a subset of the regions in memory, the technique examines the remembered set to determine whether the class set includes instances in regions outside of the subset. If the remembered set indicates that the class set includes instances outside of the subset of regions, the technique identifies the class set as “live.” This will preclude unloading the class set from the subset of regions.