A system is provided for creating a sound profile that matches sounds produced by a patient during a physical examination, such as a cardiac or pulmonary examination. A user selects multiple sounds from a library and combines them to form the profile which may then be modified by the addition of further sounds, adjustments to their relative timing, duration, loudness, and so forth. The refinement continues iteratively, and after each change the profile is provided by the system to the user, for example, as a phonocardiogram for comparison against the sounds observed during the examination.