Invention Grant
- Patent Title: Antibody to human IL-3 receptor alpha chain
- Patent Title (中): 人IL-3受体α链的抗体
-
Application No.: US13266603Application Date: 2010-04-27
-
Publication No.: US08492119B2Publication Date: 2013-07-23
- Inventor: Tomonori Tawara , Shinichiro Takayanagi , Yoshimasa Inagaki
- Applicant: Tomonori Tawara , Shinichiro Takayanagi , Yoshimasa Inagaki
- Applicant Address: JP Tokyo
- Assignee: Kyowa Hakko Kirin Co., Ltd
- Current Assignee: Kyowa Hakko Kirin Co., Ltd
- Current Assignee Address: JP Tokyo
- Agency: Sughrue Mion, PLLC
- International Application: PCT/JP2010/057510 WO 20100427
- International Announcement: WO2010/126066 WO 20101104
- Main IPC: C07K16/28
- IPC: C07K16/28 ; A61K39/395 ; C12N15/63
Abstract:
The present invention provides an antibody to human IL-3Rα chain, which does not inhibit IL-3 signaling and binds to B domain of the human IL-3Rα chain but does not bind to C domain of the human IL-3Rα chain; a composition for preventing or treating a blood tumor in which a cell expressing IL-3Rα is found in bone marrow or peripheral blood of a subject, which comprises the antibody to human IL-3Rα as an active ingredient; and a method for treating a blood tumor in which a cell expressing IL-3Rα is found in bone marrow or peripheral blood, which comprises administering, to a subject, a composition comprising the IL-3Rα antibody as an active ingredient.
Public/Granted literature
- US20120070448A1 ANTI-IL-3RA ANTIBODY FOR USE IN TREATMENT OF BLOOD TUMOR Public/Granted day:2012-03-22
Information query
