Invention Grant
- Patent Title: Antibacterial peptides active in systemic infections
- Patent Title (中): 全身感染活性物质的抗菌肽
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Application No.: US12866864Application Date: 2009-02-27
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Publication No.: US08492515B2Publication Date: 2013-07-23
- Inventor: Laszlo Otvos
- Applicant: Laszlo Otvos
- Applicant Address: US PA Philadelphia
- Assignee: Temple University—Of The Commonwealth System of Higher Education
- Current Assignee: Temple University—Of The Commonwealth System of Higher Education
- Current Assignee Address: US PA Philadelphia
- Agency: Drinker Biddle & Reath LLP
- International Application: PCT/US2009/001241 WO 20090227
- International Announcement: WO2009/108347 WO 20090903
- Main IPC: A61K38/00
- IPC: A61K38/00
Abstract:
Antimicrobial peptides of the formula are provided: X1—X2—PrO—X3—X4—PrO-Arg-Pro-Tyr-Leu-Pro-X5-Pro-Arg-Pro-Pro-Arg-Pro-Y, wherein X1 is a natural or non-natural amino acid having a free amino group or 1-amino-cyclohexyl carboxylic acid, X2 is Arg or N-methyl-Arg, X3 is Asp or GIu, X4 is Arg or Lys, X5 is Arg or Lys, and Y is Arg, Arg-NH2, N-methyl-Arg, N-methyl-Arg-NH2, Val-Arg, Val-Arg-NH2, Val-(N-methyl-Arg), or Val-(N-methyl)-Arg-NH2, and salts thereof.
Public/Granted literature
- US20100323951A1 ANTIBACTERIAL PEPTIDES ACTIVE IN SYSTEMIC INFECTIONS Public/Granted day:2010-12-23
Information query
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