Invention Grant
- Patent Title: Attenuated chimeric flavivirus bearing attenuated japanese encephalitis virus gene as backbone
- Patent Title (中): 减毒的日本脑炎病毒基因的减毒嵌合黄病毒为骨架
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Application No.: US12292518Application Date: 2008-11-20
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Publication No.: US08492532B2Publication Date: 2013-07-23
- Inventor: Kouichi Morita , Takeshi Nabeshima , Shinichi Miyake , Toshiyuki Onishi , Isao Fuke , Toyokazu Ishikawa , Hideo Goda , Masahide Ishibashi , Michiaki Takahashi
- Applicant: Kouichi Morita , Takeshi Nabeshima , Shinichi Miyake , Toshiyuki Onishi , Isao Fuke , Toyokazu Ishikawa , Hideo Goda , Masahide Ishibashi , Michiaki Takahashi
- Applicant Address: JP Osaka
- Assignee: The Research Foundation for Microbial Diseases of Osaka University
- Current Assignee: The Research Foundation for Microbial Diseases of Osaka University
- Current Assignee Address: JP Osaka
- Agency: Wenderoth, Lind & Ponack, L.L.P.
- Priority: JP2004-374630 20041224
- Main IPC: C12N7/00
- IPC: C12N7/00 ; A61K39/12
Abstract:
A nucleic acid molecule containing nucleotide sequences that encode the capsid protein, pre-membrane protein and non-structural protein of Japanese encephalitis virus, and a nucleotide sequence that encodes the envelop protein of a second flavivirus, wherein the nucleotide sequence(s) that encode(s) the pre-membrane protein and/or non-structural protein of Japanese encephalitis virus contain(s) nucleotide mutations that produce one or more amino acid mutations that attenuate the virus.
Public/Granted literature
- US20090104702A1 Attenuated chimeric flavivirus bearing attenuated Japanese encephalitis virus gene as backbone Public/Granted day:2009-04-23
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