Invention Grant
US08492539B2 Preparation of 2′-fluoro-2′-alkyl-substituted or other optionally substituted ribofuranosyl pyrimidines and purines and their derivatives
有权
2'-氟-2'-烷基取代或其它任选取代的呋喃核糖嘧啶嘧啶和嘌呤及其衍生物的制备
- Patent Title: Preparation of 2′-fluoro-2′-alkyl-substituted or other optionally substituted ribofuranosyl pyrimidines and purines and their derivatives
- Patent Title (中): 2'-氟-2'-烷基取代或其它任选取代的呋喃核糖嘧啶嘧啶和嘌呤及其衍生物的制备
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Application No.: US11225425Application Date: 2005-09-13
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Publication No.: US08492539B2Publication Date: 2013-07-23
- Inventor: Byoung-Kwon Chun , Peiyuan Wang , Jinfa Du , Suguna Rachakonda
- Applicant: Byoung-Kwon Chun , Peiyuan Wang , Jinfa Du , Suguna Rachakonda
- Applicant Address: US CA Foster City
- Assignee: Gilead Pharmasset LLC
- Current Assignee: Gilead Pharmasset LLC
- Current Assignee Address: US CA Foster City
- Agency: Fitzpatrick, Cella, Harper & Scinto
- Main IPC: C07H1/00
- IPC: C07H1/00 ; C07H3/00 ; C07H19/00 ; C07H21/00 ; C07D307/00
Abstract:
The present invention provides (i) processes for preparing a 2′-deoxy-2′-fluoro-2′-methyl-D-ribonolactone derivatives, (ii) conversion of intermediate lactones to nucleosides with potent anti-HCV activity, and their analogues, and (iii) methods to prepare the anti-HCV nucleosides containing the 2′-deoxy-2′-fluoro-2′-C-methyl-β-D-ribofuranosyl nucleosides from a preformed, preferably naturally-occurring, nucleoside.
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