A driving method for determining target transmittance of a liquid crystal sub-pixel is provided. The liquid crystal sub-pixel has display regions, the liquid crystal sub-pixel displays the target transmittance when liquid crystal voltage applied to each display region is equal to one other and transmittance variation of liquid crystal layer in the liquid crystal sub-pixel is S0 when variation of LC voltage ΔVLC occurs. The driving method includes selecting LC voltages in accordance with the target transmittance and area ratio of each display region; and applying each LC voltage to one of the display regions correspondingly, wherein transmittance of each display region is different from the target transmittance, the target transmittance is equal to sum of product of area ratio and transmittance of each display region, and transmittance variation of the liquid crystal layer in the liquid crystal sub-pixel is lower than S0 when variation of LC voltage ΔVLC occurs.