A scatter gather cache system and method are provided, which increase performance of scatter-gather DMA operations by reducing the time taken by the DMA engine to perform a logical to physical address translation. This is done primarily by two-dimensional caching of scatter-gather elements of selected scatter-gather lists using a novel indexing, line swapping and replacement methodology. The cache can also include a context victim table (CVT) for storing scatter-gather list contexts from evicted cache entries and also allows for pre-fetching of SGL elements from Scatter-Gather Lists (SGL). It also provides coherency support when there are multiple instances of the cache accessing the same memory space.