A scan chain security capability is provided herein. The scan chain security capability enables secure control over normal use of a scan chain of a system, e.g., for purposes such as testing prior to deployment or sale of the system, in-field testing after deployment or sale of the system, in-field modification of the system, and the like. The scan chain security capability enables secure control over normal use of a scan chain by enabling control over interruption of a scan chain and re-establishment of an interrupted scan chain. A scan chain security component is configured for removing an open-circuit condition from the scan chain in response to a control signal. The control signal may be generated in response to validation of a security key, in response to successful completion of a challenge-based authentication process, or in response to any other suitable validation or authentication. The scan chain security component also may be configured for creating an open-circuit condition in the scan chain in response to a second control signal. The second control signal may be a scan register value received via the scan chain.