Disclosed are medical probe devices and methods for use guiding of percutaneous probes during medical procedures. The probe devices include a clamp that can secure a probe at a targeted location. The devices can be utilized to guide a probe through the probe guide to a percutaneous target. Disclosed clamps can be utilized on probe devices incorporating an ultrasound transducer. In addition, the devices can include a sterilizable shield including a sterile probe guide for use in procedures requiring a sterile field. The sterilizable shield can be a single-use shield that can prevent contamination and re-use of the shield. The devices can define a beneficial geometry conducive to use by a single operator that can be utilized for percutaneous targets near the skin surface.